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Supplements and careful dietary planning may be necessary

While GIP exerts insulinotropic effects on pancreatic -cells, its potency is lower than that of GLP-1

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Second, kidney injury in diabetes appears to be related to glomerular hyperfiltration [93, 94], which is likely related to an excessive reabsorption of sodium in the proximal tubule, leading diminished delivery of sodium to the macula densa, and (via tubuloglomerular feedback) to afferent arteriolar dilatation [95, 96]